Family: Emporer Isaac II Angelus / Irene Palaiologos (F22598)
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 | Andronicus Angelus (1125- )
|
 | Euphrosyne Castamonita (1125- ) |
| Emporer Isaac II Angelus (1156-1204)
|
| Irene Palaiologos (1150- ) |
| Irene Angelica (1175-1208)  |